Imam Ja’far al-Sadiq, the sixth Shi’a Imam, played a major role during the scientific movement in the early 2nd century Hijrah, more so compared to that of other Imams from the Prophet’s progeny. Several factors rendered this era a golden opportunity for the Imam to spread his knowledge: the Umayyids’ and Abbasids’ preoccupation with their struggle to attain power, the scholars acquaintance with the teachings of the Ahlul Bayt, the general thirst for knowledge during this era, and Imam al-Sadiq’s prominence in both religious and natural sciences. A meticulous study of the works of Qur’anic exegesis, jurisprudence, history, and hadith studies depict the Imam’s great contributions in science and politics. This article focuses on the Imam’s role in developing this scientific movement, offers an account of the number and religious denominations of his students and narrators, and reveals the degree to which this influence extended to include Sunni literature of Islamic studies. Indeed, many scholars and students are indebted to the Imam’s vast knowledge and contributions in religious and academic fields.