Salam (Peace) is a Qur’anic term with a wide range of deep meanings and various practical aspects and manifestations. This divine word is a name of Allah, and many hadiths have been reported from the Holy Prophet and Imams regarding its meanings. In many religious texts, including prayers, ziyarahs, and social interactions, its manifestations are clearly seen. As the best deed and act of worship and the most beautiful display of servitude to Allah, prayer has some elements, including Salam. This article first identifies and summarizes the most important meanings of Salam on the basis of authentic Arabic and Persian dictionaries. Next, on the basis of these meanings, the most significant implications will be investigated, namely, the philosophy of Salam in Prayer.