In this paper, Ayatollah Murtada Mutahhari emphasizes on the importance of pursuing knowledge and its obligation upon all Muslim men and women. He presents four narrations by the Prophet Mohammad (S) on this topic which reveals that knowledge can be acquired by anyone, at any time and place. Though Islam historically made great contributions to science, Mutahhari attempts to provide answers as to why the Prophet’s commands have not been fully accomplished in the recent centuries. Nonetheless, he states that knowledge is dependent on the needs of a society to create an independent and unyielding Islamic civilization. This paper is based on a lecture delivered by Ayatollah Murtada Mutahhari on the 29th Bahman, 1340 (18th of February, 1962) in Farsi, published in Dah Goftār, the Monthly Religious Community. It is translated into English for the Message of Thaqalayn by Reza Farajian. When needed, changes are made by the editing team of the Message of Thaqalayn.